Self-described genius, aspiring cartoonist, and sixth-grade detention record holder Big Nate navigates the trials and tribulations of life in the halls of P.S. 38 with his classmates Gina, Artur, Francis, Jenny and Teddy.

Jamie Kelly shares with her diary her excitement about the fact that students from Wodehouse Middle School will be going to Mackerel Middle School temporarily.

Nervous about middle school because her family does not get her and her friends know exactly what they want to do, Abbie Wu searches for her own passion before discovering a knack for leadership when injustices in the cafeteria come to light.

When seventh-grader Jake McQuade mistakes the world's first ingestible knowledge pills for jelly beans, he suddenly knows all about physics and geometry and can speak Swahili (though Spanish would be a lot more useful)--but his sort-of girlfriend Grace thinks they can use his new found brilliance to save their middle school from the new principal, who is conspiring to get it shut down.

Although Jeff and Tad, encouraged by a new friend, Lindsey, make a deal to help one another overcome aftereffects of their cancer treatments in preparation for eighth-grade graduation, Jeff still craves advice from his older brother Stephen, who is studying drums in Africa.

When eighth-grader Cameron Boxer creates the Positive Action Group at school he intends it as a diversion to fool his parents, teachers, and sister into letting him continue to concentrate on his video-gaming--but before he knows it other kids are taking it seriously, and soon the boy who never cared about anything becomes the center of everything, whether he likes it or not.

Twelve-year-old Jacky "Ha-Ha" Hart is a class clown with a penchant for pranking--and when she's required to act in the school play to appease her frustrated teachers, she must conquer her stutter.

Oliver and Nathan, determined to get to the bottom of their new homeroom teacher's fishy behavior, discover Mr. Aidact is actually an AI robot from a secret experimental program.

Twelve-year-olds Kate and Marylin, friends since preschool, draw further apart as Marylin becomes involved in student government and cheerleading, while Kate wants to play guitar and write songs, and both develop unlikely friendships with other girls and boys.

Jamie is upset because she is now automatic friends with her old enemy Angeline, and so she tries to find something that she and her real friend, Isabella, can do together for the school talent show without Angeline.