Retiring from his Nowhere Man activities in exchange for an unofficial pardon, former government assassin Evan Smoak is entreated by a unlikely client to help rescue a fellow orphan from a dangerous foster home.

When the man who raised and trained him warns him that secret government forces are trying to eliminate all surviving members of the Orphan Program, Evan Smoak is challenged to track down and protect his teacher's last protegé from a brutal new Program leader.

Embarking on a rafting and hiking tour through southern Mexico, single mom Eve spots a man throwing machetes at a human-shaped target before finding a missing woman's digital camera containing images of the same man.