Frustrated at life with an autistic brother, twelve-year-old Catherine longs for a normal existence but her world is further complicated by a friendship with a young paraplegic.

Thirteen-year-old Sunny, accompanied by a stray dog, takes advantage of a windfall to travel from her Nebraska foster home to Enumclaw, Washington, to find the twin sister from whom she was separated at age three.

When seventh-grade twins Payton and Emma switch places, they shake up the social hierarchy at their new middle school.

Xena and Xander Holmes, an American brother and sister living in London for a year, discover that Sherlock Holmes was their great-great-great grandfather when they are inducted into the Society for the Preservation of Famous Detectives and given his unsolved casebook, from which they attempt to solve the case of a famous missing painting.