When popular, sporty sister, Kristina, is diagnosed with cancer, her younger, brainy sister, Tess, is thrown into new roles as she becomes the center of the popular crowd and must be the strong one in her family.

Sydney's charismatic older brother, Peyton, has always been the center of attention in the family but when he is sent to jail, Sydney struggles to find her place at home and the world until she meets the Chathams, including gentle, protective Mac, who makes her feel seen for the first time.

After escaping imprisonment by the totalitarian regime known as the New Order, siblings Wisty and Whit Allgood, who possess magical powers, establish themselves as leaders of the Resistance, a hidden community of teenagers like themselves, hunted by the state and determined to defy its ban on the arts, magic, and all other forms of creativity.

Thirteen-year-old TJ tries to cope with the emotional upheaval in her life when the father who kidnapped her ten years earlier and raised her under a different identity is injured, and she goes to visit her recently-discovered twin sister, mother, and future stepfather.

Twelve-year-old Fern feels invisible in her family, where grumpy eighteen-year-old Sarah is working at the family restaurant, fourteen-year-old Holden is struggling with school bullies and his emerging homosexuality, and adorable, three-year-old Charlie is always the center of attention, and when tragedy strikes, the fragile bond holding the family together is stretched almost to the breaking point.

As monsters walk the streets of San Francisco, unseen by humans, three teenaged descendants of Medusa, the once-beautiful gorgon maligned in Greek mythology, must reunite and embrace their fates.

When her best friend, Austin, goes to soccer camp over the summer, thirteen-year-old Bina finds an unlikely companion in Austin's older sister, Charlie.

As they search for their missing father near their Cornwall home, Sapphy and her brother Conor learn about their family's connection to the domains of air and of water.

Now united, the three descendants of Medusa must find the gate between the human and monster world to achieve their destiny.