In an overpopulated world where all signs of nature have been obliterated and a wall has been erected to keep out plague-ridden animals, twelve-year-old Mika refuses to believe that his twin sister was killed after being abducted, and continues to search for her in spite of the dangers he faces in doing so.

Michael Vey, a fourteen-year old who has Tourette's syndrome and special electric powers, finds there are others like him, and must rely on his powers to save himself and the others from a diabolical group seeking to control them.