John Henry Cole returns to Cheyenne after a deadly assignment intending to quit his job with Ike Kelly's Detective Agency, but when he discovers that his friend and boss has been murdered, he strikes out to bring the killer to justice.

Violence erupts over booze in the Texas town of Red Horse. A play, The Devil's Brew, which demands the abolition of liquor, is greeted with gunfire. The author is brutally murdered, and the cast threatened with death. Detective Rance Dehner quickly discovers that no one in the cast of the play believes in abolition. They are struggling actors trying to make a living. But powerful forces are conspiring to end the play and end their lives. Dehner must...

When potent moonshine is smuggled onto the Cherokee reservation, resulting in the death of a marshal, Jack Slade, a reformed drinker and gambler, must find the killers and put an end to the bootleggers' operation once and for all.