After a bizarre occurrence, Peter Parker, a.k.a. Spider-Man, joins forces with Wolverine to unravel a mystery that brings unexpected personal consequences for both super-heroes.

Peter Parker must face off against his best friend when Harry turns himself into the evil Hobgoblin after witnessing the death of his father, the Green Goblin.

Roxxon Oil has hired the world's greatest mercenary, Silver Sable, to find out what Spider-Man knows about Roxxon Oil's enemies, and he must deal with that as well as the fact that he has broken up with his girlfriend.

"When the nightmare dimension known as Gemworld invades Metropolis, teen heroes Wonder Girl, Robin and Impulse answer the call to face the threat as a reborn Young Justice, joined by Amethyst, Princess of Gemworld, and new heroes Jinny Hex--a seeming descendant of legendary bounty hunter Jonah Hex--and a new emerald warrior reluctantly called Teen Lantern. But they're shocked to discover the battle may be the key to the return of Conner Kent, a.k.a....

With Nick Fury's approval and a new Spider-Man costume given to him by Spider-Woman, Miles Morales continues to try to fill the shoes of the dead Peter Parker, while dealing with his uncle Aaron, a.k.a. the Prowler, who knows his secret.

Individually, these four heroes have been on the front lines of the battle to keep the streets of the city safe and secure. But now, with a deadly enemy from the dim past making a major move to unite the underworld, Daredevil, Luke Cage, Jessica Jones and Iron Fist must become the next great super team, The Defenders.