A decade after scientists discover that everyone has a "soulmate gene" that they share with just one other person, five people meet their matches, only to be torn by shocking secrets.

Tells the story of Rosalind Franklin, who, despite an environment of harassment and bullying in the late 1940s and 1950s, worked in a stringent, scientific manner and became one of the first scientists to map the structure of DNA.

Grace, sixteen, fears that she will succumb to the schizophrenia that took her mother away, while she and her father work for a genetics lab rushing to find a cure.

After the murder of his father, Noah Shaw uses his inheritance to move to New York with his girlfriend Mara Dyer and their friends, where they investigate the suicides of other Carriers and their Gifts begin to lead them on diverging paths.