Spanning the years 1900 to 1977, and set in Kerala, on South India’s Malabar Coast, an epic of love, faith and medicine follows three generations of a family that suffers a peculiar affliction: in every generation, at least one person dies by drowning.

Decades after a tragedy tore their family apart, four sisters reunite at their childhood vacation spot on Cape Cod, where they try to uncover the truth about the past to find their future as a family.

Housekeeper Mrs. Jeffries and her employer, Inspector Gerald Witherspoon, investigate the drowning of the owner of a medical supply company, a man without greedy relatives or business rivals but a flair for amateur sleuthing that may have caused his murder.