In parallel stories, Bone, an orphaned dog, finds and loses a series of homes, Molly, a family pet, helps Charlie through the grief and other after-effects of his brother's death, and lonely Henry pleads for a dog of his own.

In a remote area of Alaska, twelve-year-old Willow helps her father with their sled dogs when she is not at school, wishing she were more popular, all the while unaware that the animals surrounding her carry the spirits of dead ancestors and friends who care for her.

Eleven-year-old Charlotte is not a dog person but does not like that the rest of her family neglects their Saint Bernard puppy, and so with a lot of determination and a little sneakiness, she works on finding a good home for the gentle giant.