When disgraced doctor Daisuke Ido finds the detached head of a cyborg woman who has no memories, he names her Alita and attaches the head to a powerful new body that allows the reborn cyborg to track down those who prey on the weak.

Aisha Un-Haad, seventeen, and Key Tanaka, eighteen, have risked everything for new lives as mechanically enhanced soldiers, and when an insurrection forces dark secrets to surface, the fate of humanity is in their hands.